Motif ID: FOX{F1,F2,J1}.p2

Z-value: 1.400


Transcription factors associated with FOX{F1,F2,J1}.p2:

Gene SymbolEntrez IDGene Name
FOXF1 2294 forkhead box F1
FOXF2 2295 forkhead box F2
FOXJ1 2302 forkhead box J1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXF2chr6_+_1335067-0.523.7e-02Click!
FOXF1chr16_+_85101605-0.504.6e-02Click!
FOXJ1chr17_-_716489650.292.7e-01Click!


Activity profile for motif FOX{F1,F2,J1}.p2.

activity profile for motif FOX{F1,F2,J1}.p2


Sorted Z-values histogram for motif FOX{F1,F2,J1}.p2

Sorted Z-values for motif FOX{F1,F2,J1}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{F1,F2,J1}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_159459814 4.056 APOA2
apolipoprotein A-II
chr1_-_159459999 4.042 NM_001643
APOA2
apolipoprotein A-II
chr11_-_117589283 3.030 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr7_+_134483305 3.026 NM_018295
TMEM140
transmembrane protein 140
chr5_-_42847716 2.928 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr22_+_19458378 2.861 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr17_+_69939130 2.817 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr14_-_20562962 2.612 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr17_-_7023283 2.580 ASGR1
asialoglycoprotein receptor 1
chr12_-_51629874 2.417 KRT8
keratin 8
chr20_-_45410033 2.414 ZMYND8
zinc finger, MYND-type containing 8
chr16_-_11282595 2.351 NM_002761
PRM1
protamine 1
chr6_-_41823056 2.224 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr3_+_173043832 2.147 NM_001164436
TMEM212
transmembrane protein 212
chr1_-_57204208 2.087 NM_000066
C8B
complement component 8, beta polypeptide
chr13_+_49658016 2.073


chr2_-_233586145 2.059 NGEF
neuronal guanine nucleotide exchange factor
chr17_-_7023378 2.054 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr2_-_233586164 2.023 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr2_-_165133239 2.003 GRB14
growth factor receptor-bound protein 14
chr10_-_91395194 1.967 NM_148977
PANK1
pantothenate kinase 1
chr12_+_119900677 1.883 HNF1A
HNF1 homeobox A
chr12_+_119900931 1.843 NM_000545
HNF1A
HNF1 homeobox A
chr4_+_100714995 1.828 MTTP
microsomal triglyceride transfer protein
chr1_+_116455898 1.821 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr6_-_26038817 1.712 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr1_-_167822248 1.702 F5
coagulation factor V (proaccelerin, labile factor)
chr17_-_36418869 1.659 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr17_+_3324096 1.640 NM_001128085
ASPA
aspartoacylase
chr12_-_101835026 1.604 PAH
phenylalanine hydroxylase
chr6_-_138862271 1.595 NM_001144060
NHSL1
NHS-like 1
chr6_-_138862273 1.581


chr6_+_64289585 1.563 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr4_+_69716298 1.520 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr16_-_66590856 1.499 NM_022355
DPEP2
dipeptidase 2
chr19_+_18357966 1.477 NM_004864
GDF15
growth differentiation factor 15
chr1_-_167822334 1.466 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr1_-_47468029 1.417 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr13_-_45654327 1.407 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr13_-_45654292 1.405 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_40635058 1.378 NM_001198980
SMAP2
small ArfGAP2
chr13_-_45654296 1.378 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_144149794 1.361 NM_006472
TXNIP
thioredoxin interacting protein
chr8_-_30121741 1.348 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr14_+_104338423 1.345 ZBTB42
zinc finger and BTB domain containing 42
chr6_+_32003180 1.343 NM_000063
NM_001145903
C2

complement component 2

chr10_-_52315390 1.328 A1CF
APOBEC1 complementation factor
chr7_+_50318801 1.324 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr14_+_104337923 1.309 NM_001137601
ZBTB42
zinc finger and BTB domain containing 42
chr5_+_147754467 1.298 FBXO38
F-box protein 38
chr14_-_93859394 1.269 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr14_+_31868229 1.265 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr2_+_143351695 1.204 KYNU
kynureninase
chr12_-_69837831 1.197 TSPAN8
tetraspanin 8
chr2_-_39201631 1.191 SOS1
son of sevenless homolog 1 (Drosophila)
chr2_+_219354692 1.180 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr19_-_53081326 1.164 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr12_-_61615124 1.143 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr10_+_102722275 1.141 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr19_+_17723285 1.135 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr15_-_32398220 1.133 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr12_-_94914133 1.125 NM_002108
HAL
histidine ammonia-lyase
chr12_-_49076658 1.115 NM_001145475
FAM186A
family with sequence similarity 186, member A
chr17_-_23721485 1.114 NM_000638
VTN
vitronectin
chrX_+_70232362 1.109 NM_001170931
NM_005938
FOXO4

forkhead box O4

chr10_-_69267774 1.101 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr4_-_123761615 1.087 NM_021803
IL21
interleukin 21
chr10_-_52315436 1.072 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr2_-_32344192 1.058 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr11_-_46572073 1.055 AMBRA1
autophagy/beclin-1 regulator 1
chr4_-_186969041 1.039 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr2_-_43919392 1.030 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr1_-_1346465 1.013 NM_001145210
LOC441869
hypothetical protein LOC441869
chr15_-_38185578 1.009 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr17_-_23721468 1.008 VTN
vitronectin
chr12_+_27740694 1.007 NM_001029874
REP15
RAB15 effector protein
chr1_-_205161821 0.996 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr5_+_154072654 0.971 NM_015315
LARP1
La ribonucleoprotein domain family, member 1
chr17_-_23721430 0.968 VTN
vitronectin
chr11_-_46572160 0.952 AMBRA1
autophagy/beclin-1 regulator 1
chr10_-_54201400 0.950 NM_000242
MBL2
mannose-binding lectin (protein C) 2, soluble
chr10_+_60606352 0.949 NM_032439
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr4_+_74488835 0.942 NM_000477
ALB
albumin
chr13_-_48873735 0.931 NM_030925
CAB39L
calcium binding protein 39-like
chr12_-_69838045 0.930 NM_004616
TSPAN8
tetraspanin 8
chrX_-_48578878 0.928 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr7_+_111850367 0.927 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr2_+_143351536 0.927 NM_001032998
NM_003937
KYNU

kynureninase

chr4_+_74488910 0.924 ALB
albumin
chr6_+_32230172 0.916 PPT2
palmitoyl-protein thioesterase 2
chr5_+_137701122 0.896 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr7_+_149733309 0.888


chr17_-_23721420 0.884 VTN
vitronectin
chr9_-_115880494 0.878 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr2_-_21084077 0.873 APOB
apolipoprotein B (including Ag(x) antigen)
chr4_+_39084867 0.869 NM_175737
KLB
klotho beta
chr2_+_176761552 0.865 NM_024501
HOXD1
homeobox D1
chr9_-_85622366 0.854 NM_001135953
NM_025211
GKAP1

G kinase anchoring protein 1

chr16_+_52027020 0.852 RBL2
retinoblastoma-like 2 (p130)
chr7_-_140270749 0.848 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr2_+_86800940 0.847 RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr1_+_149877955 0.846 SNX27
sorting nexin family member 27
chr2_-_180319013 0.843 NM_001113397
ZNF385B
zinc finger protein 385B
chrX_+_46825179 0.842 RGN
regucalcin (senescence marker protein-30)
chr14_+_94148466 0.841 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr3_+_99934227 0.831 NM_006100
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr3_-_58497913 0.826 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr2_+_86800898 0.819 NM_022780
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr17_-_23721351 0.818 VTN
vitronectin
chr9_-_115880366 0.813 AMBP
alpha-1-microglobulin/bikunin precursor
chr6_+_32229599 0.809 NM_005155
PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chr20_-_22514092 0.805 NM_153675
FOXA2
forkhead box A2
chr4_-_186969202 0.805 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr7_+_106292975 0.805 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr7_+_1094248 0.800 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr18_+_53863865 0.791 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_190811479 0.785 NM_002922
RGS1
regulator of G-protein signaling 1
chr16_+_11346780 0.782 NM_152308
C16orf75
chromosome 16 open reading frame 75
chr15_-_38185865 0.780 NM_033503
BMF
Bcl2 modifying factor
chr4_+_39084936 0.773 KLB
klotho beta
chr2_+_169637255 0.772 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr4_-_155731288 0.768 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr19_-_47638890 0.767 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr6_-_31740466 0.763 GPANK1
G patch domain and ankyrin repeats 1
chr9_-_115880281 0.761 AMBP
alpha-1-microglobulin/bikunin precursor
chr5_-_59819642 0.760 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chrX_-_153698930 0.755 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr3_-_10522267 0.752 NM_001001331
NM_001683
ATP2B2

ATPase, Ca++ transporting, plasma membrane 2

chr17_+_69950782 0.743 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr18_+_59726183 0.739 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr9_+_135276940 0.734 NM_139025
NM_139026
NM_139027
ADAMTS13


ADAM metallopeptidase with thrombospondin type 1 motif, 13


chr5_+_137701601 0.731 NM_016605
FAM53C
family with sequence similarity 53, member C
chr15_-_38387357 0.728 PLCB2
phospholipase C, beta 2
chr1_+_111483771 0.720 NM_001007794
CEPT1
choline/ethanolamine phosphotransferase 1
chr15_-_38387410 0.717 NM_004573
PLCB2
phospholipase C, beta 2
chr8_+_82807218 0.715 NM_152284
CHMP4C
chromatin modifying protein 4C
chr1_-_24067347 0.696 NM_000147
FUCA1
fucosidase, alpha-L- 1, tissue
chr19_+_15612706 0.690 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr9_+_132990760 0.690 NM_005085
NUP214
nucleoporin 214kDa
chr11_+_22644732 0.687 NM_001143830
GAS2
growth arrest-specific 2
chr10_-_50066386 0.685 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr4_-_111339201 0.684 NM_001130721
NM_024090
ELOVL6

ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)

chr2_+_11591692 0.676 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr6_+_30238961 0.672 NM_033229
TRIM15
tripartite motif containing 15
chr3_-_71376919 0.671 FOXP1
forkhead box P1
chr11_-_116213511 0.665 NM_000039
APOA1
apolipoprotein A-I
chr4_+_22608252 0.660


chr15_-_38387164 0.658 PLCB2
phospholipase C, beta 2
chr12_-_31370305 0.657 FAM60A
family with sequence similarity 60, member A
chr6_+_43135606 0.648 NM_201523
KLC4
kinesin light chain 4
chr17_-_73636386 0.640 NM_001127198
TMC6
transmembrane channel-like 6
chr2_+_113601608 0.636 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr5_+_137701852 0.636 FAM53C
family with sequence similarity 53, member C
chr5_-_169657360 0.634 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr17_+_70244945 0.633 NM_001006638
NM_001163990
RAB37

RAB37, member RAS oncogene family

chr19_-_51979838 0.629 NM_001145145
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr2_+_43919606 0.628 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr2_-_39310176 0.625 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr2_+_201756048 0.623 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr5_-_169657395 0.621 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr8_-_110724594 0.620 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr12_-_31370351 0.617 FAM60A
family with sequence similarity 60, member A
chr14_+_20226762 0.617 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr9_-_115880372 0.614 AMBP
alpha-1-microglobulin/bikunin precursor
chr6_+_17708483 0.610 NM_016255
FAM8A1
family with sequence similarity 8, member A1
chr5_-_169657312 0.609 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr4_+_187424111 0.609 NM_000128
F11
coagulation factor XI
chr6_+_154373323 0.604 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr12_-_31370387 0.603 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr16_+_11346812 0.600 C16orf75
chromosome 16 open reading frame 75
chr6_-_43135092 0.599 NM_015950
MRPL2
mitochondrial ribosomal protein L2
chr10_+_7785347 0.598 ITIH2
inter-alpha (globulin) inhibitor H2
chr1_-_229627412 0.594 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr10_+_5126589 0.591 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr5_+_137701855 0.591 FAM53C
family with sequence similarity 53, member C
chr11_-_102331643 0.590 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr15_+_21361546 0.585 NM_005664
MKRN3
makorin ring finger protein 3
chr2_-_128332143 0.579 POLR2D
polymerase (RNA) II (DNA directed) polypeptide D
chr18_-_50777634 0.578 NM_025214
CCDC68
coiled-coil domain containing 68
chr17_+_75366524 0.577 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr17_-_6958695 0.573 ASGR2
asialoglycoprotein receptor 2
chr2_+_113601616 0.572 IL1RN
interleukin 1 receptor antagonist
chr2_+_168383427 0.567 NM_020981
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr6_+_32229771 0.567 PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chr10_+_114144512 0.566 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_+_86801081 0.565 RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr4_+_74491272 0.558 ALB
albumin
chr11_-_114880275 0.555 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr12_+_120726317 0.549 SETD1B
SET domain containing 1B
chr4_+_187424336 0.544 F11
coagulation factor XI
chr10_+_7785331 0.544 ITIH2
inter-alpha (globulin) inhibitor H2
chr1_+_196874867 0.543 PTPRC
protein tyrosine phosphatase, receptor type, C
chr12_+_9033403 0.539 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr3_-_10522340 0.539 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr7_+_106293112 0.536 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr4_+_71096830 0.535 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr12_+_52121699 0.532 NM_001005354
NM_018457
PRR13

proline rich 13

chr2_-_128332161 0.531 POLR2D
polymerase (RNA) II (DNA directed) polypeptide D
chr17_-_72151314 0.526 NM_018414
ST6GALNAC1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
chr2_-_87156616 0.525 LOC285074
anaphase promoting complex subunit 1 pseudogene

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.19 1.33e-02 GO:0050896 response to stimulus
4.55 3.74e-02 GO:0008206 bile acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.26 4.01e-04 GO:0071944 cell periphery
1.27 4.04e-04 GO:0005886 plasma membrane
1.14 1.48e-02 GO:0016020 membrane
1.18 3.05e-02 GO:0016021 integral to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.67 1.07e-03 GO:0004930 G-protein coupled receptor activity
1.52 2.00e-03 GO:0004888 transmembrane receptor activity
1.39 1.67e-02 GO:0004872 receptor activity
1.34 2.08e-02 GO:0004871 signal transducer activity
1.34 2.08e-02 GO:0060089 molecular transducer activity
2.96 2.90e-02 GO:0008081 phosphoric diester hydrolase activity